If you're asking about Quake, then any changes made on the Options screens should be automatically saved on exit. If not and you're running Windows, maybe Quake is in a folder located where it doesn't have write permissions. You can also try putting the settings in an autoexec.bat file in the ID1 folder 

autoexec.cfg he means 

https://pbs.twimg.com/media/CegMFrsW8AE7SMS.jpg:orig 

... the new pornQuake edition 

That depends on which engine you're using. Vanilla Quake engines only saves the resolution if you press D into the Video Options menu.

Brightness is usually always saved. 

I think he uses JoeQuake so he'd need to type cfg_savevars 1 in the console. 

quakespasm -heapsize 64000 -game quoth -zone 4096 -width 1600 -height 1200
after each start game is bright no matter what 

autoexec.cfg file, write
viewsize "100.000000"
gamma "0.990000"
scr_menuscale "1.5"
scr_sbarscale "1.5"
thanks 

I decided to play through some old-school Quake maps and thought it would be fun to pick on a mapper who had released several maps so that I could gauge 'improvement' as time moved on.

I used the maps listed at Quaddicted.com and selected Neil Manke's maps for no reason other than it was a name I recognised, and I remembered that he went on to create some HL maps.

However, I then Googled him to see what he was up to now (nearly 20 years after his maps I am playing) and ran into some kind of 'conspiracy' scenario with reports of him suddenly disappearing half way through a new gaming project. The thing is, there are reports of him being ill, suggestions that he had died, but a constant stream of 'nobody knows the truth'.

Does anyone here know what happened? Did he die and if not, why did he disappear? Did he ever get back into mapping for any games? 

For starters, lose the 1990s command line

-heapsize 64000 <--- not needed
-width 1600 -height 1200 <-- not needed
-zone 4096 <--- not needed

-game quoth <---- this is entirely wrong
and should instead be -quoth if you were to put it in the command line --- except you can do "game warpspasm -quoth" in the console

so again, not needed. 

Is actually less than the current QS default. 

tbf, every map readme up until quite recently is gonna tell the player to stick all that crap in... 

Ironically, with a standard engine it will save the config to the current gamedir.

So if you switch the gamedir during run, when you start the engine next it will lose all changes.

Mark V fixes that by saving the config in the directory that was engine load gamedir.

1) If you start Mark V with no command line, the config will save in id1, even if you changed the gamedir.

2) If you start Mark V with -game <something>, it will save the config in <something>

In both cases, this is the desired result.

This may be why Jamomir is having what looks like "my settings don't save" in Quakespasm. 

https://en.wikipedia.org/wiki/Black_Widow_Games

I never heard that he disappeared, maybe he's just not doing any maps and game dev any more? 

It's hard to believe he'd be this guy�
http://www.manke.com/about.html

Well, the logical first step would be to try asking about him to his ex-partners from Black Widow Games. 

not sure, seems to be a duplicate name. 

haha, I don't think that's the same guy =) 

But that only adds 'fuel to the fire', which of course may not actually be burning.

The Wiki links don't seem to get you anywhere, and NM's name link doesn't exist. The Black Widow site is up but with no entries since 2008. E-mails just get bounced.

It's quite interesting. 

possible to have this effect around laserbolts/explosions/shoooting grunts in other mod than Quoth pls? 

that's actually not part of quoth. simply set 'gl_flashblend' to 1. 

No. Set it to 0. 

to the *.bat file, ok, thanks 

whats the best +r_wateralpha settings to have transparent glass but not broken lava/slime pls? 

+gl_flashblend 1 to the *.bat file, ok, thanks

Like negke said: no, set it to 0.