remember this: http://www.continuitygame.com/index.html

it has two modes, one where you play a single tile, running and jumping like mario or something and then you could switch to the 'over map' where you could rearrange where each tile was in relation to the others.

the music has two tracks that were played synchronously. when you were at single tile mode where you jump and run, the music was louder with drums and harsh synths and when you zoomed out into the 'over map' mode, where you had to think and rearrange tiles, the music lost all of the drums and almost became just pads and piano and soothing synths.

you can see how it really completely changes the way you interpret both aspects of the game, and it's definitely the second one that would work.
i guess the real barrier is finding someone who could do it. :S