Recorded a playthrough on "+Quoth Nightmare", i.e. "skill 3; coop 2". A while ago actually, but youtube was being fussy. In 4k or as demos.

IMO that the coop flag makes this masterpiece even more masterpiecey. Gugs and droles are less exploitable and a fairer challenge (esp. in ambushes) than shamblers, extra deathlords make ammo management a bit tougher, and I prefer gaunts to vores as well. Vorelings don't work as tarbaby replacements at all though.
It isn't fully coop-compatible: GL secret in warpa softlocks warpb, and half of warpd can be skipped by picking up the same keycard multiple times.
Other than that, what's there to say? It's still the best.